Publications

  • Taxidis J, Pnevmatikakis EA, Dorian CC, Mylavarapu AL, Arora JS, Samadian KD, Hoffberg EA. Golshani P. Differential Emergence and Stability of Sensory and Temporal Representations in Context-Specific Hippocampal Sequences. Neuron. 2020.
  • Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020.
  • Lazaro MT*, Taxidis J*, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, Choe KY, Peñagarikano O, Masmanidis SC, Rácz B, Xu X, Geschwind DH, Golshani P. Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Rep. 2019.
  • Arac A, Zhao P, Dobkin BH, Carmichael ST, Golshani P. DeepBehavior: A Deep Learning Toolbox for Automated Analysis of Animal and Human Behavior Imaging Data. Front Syst Neurosci. 2019.
  • Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy. Nat Methods. 2019.
  • Shuman T, Amendolara B, Golshani P. Theta Rhythmopathy as a Cause of Cognitive Disability in TLE. Epilepsy Curr. 2017.
  • Einstein MC, Polack PO, Tran DT, Golshani P. Visually Evoked 3-5 Hz Membrane Potential Oscillations Reduce the Responsiveness of Visual Cortex Neurons in Awake Behaving Mice. J Neurosci. 2017.
  • Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016.
  • Lázaro MT, Golshani P. The utility of rodent models of autism spectrum disorders. Curr Opin Neurol. 2015.
  • Garcia-Junco-Clemente P, Golshani P. PTEN: A master regulator of neuronal structure, function, and plasticity. Commun Integr Biol. 2014.
  • Mehta SQ, Golshani P. Clinical neurogenetics: autism spectrum disorders. Neurol Clin. 2013.
  • Polack PO, Friedman J, Golshani P. Cellular mechanisms of brain state-dependent gain modulation in visual cortex. Nat Neurosci. 2013.
  • Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity. J Neurosci. 2009.
  • Golshani P, Portera-Cailliau C. In vivo 2-photon calcium imaging in layer 2/3 of mice. J Vis Exp. 2008.
  • Golshani P, Hutnick L, Schweizer F, Fan G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Relat Syst. 2005.
  • Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ. A positively tuned voltage indicator for extended electrical recordings in the brain. Nat Methods. 2023.
  • Kostin A, Alam MA, Saevskiy A, Yang C, Golshani P, Alam MN. Calcium Dynamics of the Ventrolateral Preoptic GABAergic Neurons during Spontaneous Sleep-Waking and in Response to Homeostatic Sleep Demands. Int J Mol Sci. 2023.
  • Guo C, Blair GJ, Sehgal M, Sangiuliano Jimka FN, Bellafard A, Silva AJ, Golshani P, Basso MA, Blair HT, Aharoni D. Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals. Sci Adv. 2023.
  • Chen Z, Blair GJ, Cao C, Zhou J, Aharoni D, Golshani P, Blair HT, Cong J. FPGA-Based In-Vivo Calcium Image Decoding for Closed-Loop Feedback Applications. IEEE Trans Biomed Circuits Syst. 2023.
  • Zhou S, Seay M, Taxidis J, Golshani P, Buonomano DV. Multiplexing working memory and time in the trajectories of neural networks. Nat Hum Behav. 2023.
  • Chen Z, Blair GJ, Guo C, Zhou J, Romero-Sosa JL, Izquierdo A, Golshani P, Cong J, Aharoni D, Blair HT. A hardware system for real-time decoding of in vivo calcium imaging data. Elife. 2023.
  • Barry J, Oikonomou KD, Peng A, Yu D, Yang C, Golshani P, Evans CJ, Levine MS, Cepeda C. Dissociable effects of oxycodone on behavior, calcium transient activity, and excitability of dorsolateral striatal neurons. Front Neural Circuits. 2022.
  • Choe KY, Bethlehem RAI, Safrin M, Dong H, Salman E, Li Y, Grinevich V, Golshani P, DeNardo LA, Peñagarikano O, Harris NG, Geschwind DH. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. Neuron. 2022.
  • Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021.
  • Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome. Mol Autism. 2021.
  • Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS. Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK. Neuron. 2021.
  • Hintiryan H, Bowman I, Johnson DL, Korobkova L, Zhu M, Khanjani N, Gou L, Gao L, Yamashita S, Bienkowski MS, Garcia L, Foster NN, Benavidez NL, Song MY, Lo D, Cotter KR, Becerra M, Aquino S, Cao C, Cabeen RP, Stanis J, Fayzullina M, Ustrell SA, Boesen T, Tugangui AJ, Zhang ZG, Peng B, Fanselow MS, Golshani P, Hahn JD, Wickersham IR, Ascoli GA, Zhang LI, Dong HW. Connectivity characterization of the mouse basolateral amygdalar complex. Nat Commun. 2021.
  • Saravanapandian V, Frohlich J, Hipp JF, Hyde C, Scheffler AW, Golshani P, Cook EH, Reiter LT, Senturk D, Jeste SS. Properties of beta oscillations in Dup15q syndrome. J Neurodev Disord. 2020.
  • Latifi S, Mitchell S, Habibey R, Hosseini F, Donzis E, Estrada-Sánchez AM, Nejad HR, Levine M, Golshani P, Carmichael ST. Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke. Cereb Cortex. 2020.
  • Donzis EJ, Estrada-Sánchez AM, Indersmitten T, Oikonomou K, Tran CH, Wang C, Latifi S, Golshani P, Cepeda C, Levine MS. Cortical Network Dynamics Is Altered in Mouse Models of Huntington’s Disease. Cereb Cortex. 2020.
  • Sun Y, Jin S, Lin X, Chen L, Qiao X, Jiang L, Zhou P, Johnston KG, Golshani P, Nie Q, Holmes TC, Nitz DA, Xu X. CA1-projecting subiculum neurons facilitate object-place learning. Nat Neurosci. 2019.
  • Gáspár ME, Polack PO, Golshani P, Lengyel M, Orbán G. Representational untangling by the firing rate nonlinearity in V1 simple cells. Elife. 2019.
  • Frohlich J, Reiter LT, Saravanapandian V, DiStefano C, Huberty S, Hyde C, Chamberlain S, Bearden CE, Golshani P, Irimia A, Olsen RW, Hipp JF, Jeste SS. Mechanisms underlying the EEG biomarker in Dup15q syndrome. Mol Autism. 2019.
  • Kingsbury L, Huang S, Wang J, Gu K, Golshani P, Wu YE, Hong W. Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals. Cell. 2019.
  • Wykes RC, Khoo HM, Caciagli L, Blumenfeld H, Golshani P, Kapur J, Stern JM, Bernasconi A, Dedeurwaerdere S, Bernasconi N. WONOEP appraisal: Network concept from an imaging perspective. Epilepsia. 2019.
  • Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell Rep. 2019.
  • Howe JR 6th, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018.
  • Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018.
  • Skocek O, Nöbauer T, Weilguny L, Martínez Traub F, Xia CN, Molodtsov MI, Grama A, Yamagata M, Aharoni D, Cox DD, Golshani P, Vaziri A. High-speed volumetric imaging of neuronal activity in freely moving rodents. Nat Methods. 2018.
  • Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1. Front Neural Circuits. 2018.
  • Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017.
  • Frohlich J, Senturk D, Saravanapandian V, Golshani P, Reiter LT, Sankar R, Thibert RL, DiStefano C, Huberty S, Cook EH, Jeste SS. A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome. PLoS One. 2016.
  • Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016.
  • Prevedel R, Verhoef AJ, Pernía-Andrade AJ, Weisenburger S, Huang BS, Nöbauer T, Fernández A, Delcour JE, Golshani P, Baltuska A, Vaziri A. Fast volumetric calcium imaging across multiple cortical layers using sculpted light. Nat Methods. 2016.
  • Cantero G, Liu XB, Mervis RF, Lazaro MT, Cederbaum SD, Golshani P, Lipshutz GS. Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. J Neurosci. 2016.
  • Bakhurin KI, Mac V, Golshani P, Masmanidis SC. Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice. J Neurophysiol. 2016.
  • Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH. The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. PLoS One. 2015.
  • Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS. Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo. Nat Neurosci. 2015.
  • Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med. 2015.
  • Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014.
  • Varga C, Oijala M, Lish J, Szabo GG, Bezaire M, Marchionni I, Golshani P, Soltesz I. Functional fission of parvalbumin interneuron classes during fast network events. Elife. 2014.
  • Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M. Direct reactivation of a coherent neocortical memory of context. Neuron. 2014.
  • Mantoan Ritter L, Golshani P, Takahashi K, Dufour S, Valiante T, Kokaia M. WONOEP appraisal: optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis. Epilepsia. 2014.
  • Mehta SQ, Golshani P. Clinical neurogenetics: autism spectrum disorders. Neurol Clin. 2013.
  • Garcia-Junco-Clemente P, Chow DK, Tring E, Lazaro MT, Trachtenberg JT, Golshani P. Overexpression of calcium-activated potassium channels underlies cortical dysfunction in a model of PTEN-associated autism. Proc Natl Acad Sci U S A. 2013.
  • Gonçalves JT, Anstey JE, Golshani P, Portera-Cailliau C. Circuit level defects in the developing neocortex of Fragile X mice. Nat Neurosci. 2013.
  • Varga C, Golshani P, Soltesz I. Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice. Proc Natl Acad Sci U S A. 2012.
  • Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. Associative fear learning enhances sparse network coding in primary sensory cortex. Neuron. 2012.
  • Peñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011.
  • Cheng A, Gonçalves JT, Golshani P, Arisaka K, Portera-Cailliau C. Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing. Nat Methods. 2011.
  • Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009.
  • Ratnaparkhi A, Lawless GM, Schweizer FE, Golshani P, Jackson GR. A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism. PLoS One. 2008.